Practical Reviews

BZOs Alter Chloride Ion Channels in Neurons


Gamma-aminobutyric acid A (GABA A ) type receptors are found on neurons within the central nervous system. Essentially 5 different subunits surround a pore or opening on a neuron, and these pores (ion channels) are normally closed. GABA type receptors are specific to chloride ion channels, which have 2 different GABA binding sites around each channel. GABA is a naturally occurring inhibitory neurotransmitter that, when released, binds to and activates those 2 specific GABA receptor more...
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