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Inhibitors, Inducers of CYP450 System Impact Drug Metabolism

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Some drugs undergo first-pass hepatic metabolism. The liver uses a series of microsomal drug-metabolizing enzymes (MDMEs) to accomplish this task. Some of the hepatic MDMEs are cytochrome P450 (CYP450) enzymes. Multiple subclasses exist and are substrate-specific. For example, CYP384 is a specific isozyme that breaks down the different benzodiazepines, and CYP2C19 is specific to diazepam. CYP450 enzymes are capable of metabolizing hundreds of compounds, and they also serve to help more...
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