Practical Reviews

18F-FDS -- A Highly Sensitive, Specific PET Agent for Tracking Lung Infection


Background: Preclinical studies with 2- 18 F-Fluorodeoxysorbitol ( 18 F-FDS), a positron emitting analog of sorbitol, demonstrated promising results for imaging of gram negative infection. Klebsiella pneumoniae (Kp) is a common cause of nosocomial lung infection with diagnostic and treatment challenges. Objective: To validate 18 F-FDS for imaging lung infection longitudinally. Other objectives are correlating tracer uptake with bacterial growth, and ability to differentiate lung in more...
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