Non–Mass-Like Enhancement on MRI Not As Sensitive As You May Think

Background: On breast MRI, non–mass-like enhancement had been defined in 2003 with the publishing of the fourth edition of the BI-RADS lexicon. Studies published since then have described no particular correlation between enhancement kinetics and benign or malignant pathology regarding this type of enhancement. Some morphologic features did have correlation with malignancy. Objective: To establish a more universal understanding of morphologic characteristics of non–mass-like enhancement on breast MRI in order to determine which characteristics favor malignant or benign pathology. Design: Meta-analysis. Methods: The PubMed database was searched from 2003 to 2011 in order to identify studies analyzing non–mass-like enhancement on MRI. Only studies that focused on morphology and/or enhancement kinetics of the area of enhancement were included, and case reports as well as reviews were excluded. Meta-analysis was then performed over the included studies in order to deter more...