Stress Testing With CMR Outperforms SPECT MPI for Detection of CAD

Background: Noninvasive stress testing, especially with nuclear imaging, is the cornerstone for the initial evaluation of patients with stable ischemic heart disease. The accuracy, sensitivity, and specificity vary among clinical trials. There are newer modalities including stress testing with PET and cardiovascular magnetic resonance (CMR). Objective: To assess the diagnostic accuracy of gadobutrol-enhanced vasodilator stress perfusion CMR and late gadolinium enhancement imaging to detect coronary artery disease (CAD). Design: International, multicenter, prospective phase 3 trial. Participants: Stable patients aged ≥18 years who were undergoing evaluation for known or suspected CAD and who had an indication for coronary angiography. Methods: The current paper reports the secondary aims of the GadaCAD2 (Gadobutrol/Gadavist-enhanced Cardiac Magnetic Resonance Imaging to Detect Coronary Artery Disease) trial: (1) to determine if CMR sensitivity was noninferior to SPECT myocardial pe more...