Early Stage iCDRs Are Higher With DBT Plus SM Screening Compared to DM

Background: Compared to standard digital mammography (DM), breast cancer screening with digital breast tomosynthesis (DBT) plus synthesized mammography (SM) increases the detection of invasive breast tumors. The different invasive cancer detection rates (iCDRs) between methods with regard to prognostic characteristics are unknown. Objective: To compare tumor stage, histologic grade, patient age, and breast density of invasive breast cancers detected with DBT plus SM versus DM. Design: Subanalysis of the Tomosynthesis plus Synthesized Mammography (TOSYMA) study, a multicenter randomized controlled trial in Germany. Participants: Women aged 50 to 70 years living in the catchment areas of TOSYMA site. Methods: The study compared iCDRs, rate differences, and odds ratios between DBT plus SM (test arm) and DM (control arm) and categorized patient groups by Union for International Cancer Control stages (I vs II–IV), histologic grade (1 vs 2 or 3), age group (50 to 59 years vs 60 to 70 more...