¹⁸F PSMA PET/CT Is Best Planning Method for MDTs

Background: Although androgen deprivation therapy (ADT) is commonly used for metastatic prostate cancer, this approach can cause undesired side effects that sometimes only provide limited benefit. Treatment of a few areas of metastatic prostate cancer might be effectively treated with metastasis-directed therapy (MDT) using stereotactic radiation if these lesions can be specifically located. Both choline PET/CT and prostate-specific membrane antigen (PSMA) PET/CT imaging have shown to accurately localize sites of metastatic prostate cancer. Objective: To determine whether MDT of oligometastatic prostate cancer using choline PET/CT or PSMA PET/CT imaging could result in effective cancer treatment. Design: Retrospective study. Methods: Data on patients with oligometastatic prostate cancer treated with MDT at 8 Italian cancer centers were obtained. Inclusion criteria were prostate cancer patients with up to 5 metastatic lesions located in nodal, visceral, or skeletal sites detected by c more...