PSMA PET/CT Is Better Than Prostate MRI for Recurrent PCa Detection

Background: Biochemical recurrence following radical prostatectomy for prostate cancer (PCa) is common. Detecting sites of this recurrence using imaging approaches has been challenging, but recent developments in PET and MRI have significantly advanced this capability. Objective: To compare the capability of prostate-specific membrane antigen (PSMA) PET/CT imaging versus prostate MRI to detect the sites of PCa recurrence. Design: Comprehensive literature review following the guidelines for Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Methods: The quality of the study was assessed using the Quality Assessment of Diagnostic Performance Studies (QUADAS-2) tool. Results: Although 479 studies were initially identified in the literature search, only 5 studies met inclusion criteria. These studies included 228 patients. Of 5 studies, 4 used 68 Ga as the radiolabel for PSMA, and 1 of 5 studies used 18 F as the radiolabel for PSMA. The PSMA PET/CT studies showed an over more...