Radiation to Head, Brain Can Result in RIBT After Period of Latency

Background: It is well known that radiation therapy (RT) to the brain can induce brain tumors. RT to the brain has been widely used to treat childhood cancers and certain scalp diseases such as tinea capitis. Objective: To study the characteristics of radiation-induced brain tumors (RIBTs). Design: Single-institution retrospective study of RIBTs from Japan, along with a systematic review of the topic from published series of cases. Methods: Medical records of all patients treated at this institution between 2008 and 2022 with gliomas, meningiomas, and sarcomas were reviewed, and patients who had undergone previous RT were identified. Criteria for diagnosing RIBT were as follows: tumor arose within the radiated field, the secondary tumor was histologically different from the primary tumor, there was a sufficient latency period between RT and RIBT, and patients did not have a genetic history of cancer predisposition (eg, Li-Fraumeni syndrome). Systematic review was based on PRISMA (Pre more...