Genetic Variants Influence Risk, Severity of DAVFs

Background: Dural arteriovenous fistulas (DAVFs) account for 10% to 15% of all intracranial vascular malformations. Their pathogenesis is likely associated with thrombosis of venous sinuses or cortical veins and may be influenced by increased systemic thrombotic activity, hormonal changes (eg, oral contraceptive use, pregnancy, and menopause), prior head trauma or cranial surgery, and infections such as otitis or sinusitis. Certain coagulation-related single-nucleotide polymorphisms (SNPs) may also be associated with the formation of these vascular malformations. Objective: To explore the relationship among SNPs, coagulation test results, and the angioarchitecture of DAVFs. Design: Single-center retrospective analysis. Methods: 118 Chinese patients with DAVFs treated between June 2021 and May 2024 were included. Pregnant or lactating women and patients with long-term use of oral contraceptives were excluded. For patients with a history of anticoagulant or antiplatelet use, coagulatio more...