Assessing Changes in Juvenile RRP With HPV Vaccination

Background: Juvenile-onset recurrent respiratory papillomatosis (JORRP) may cause severe morbidity including poor voice, scarring of the larynx, and tracheostomy dependence in affected children. Human papillomavirus (HPV) vaccination targets low-risk types such as 6 and 11, which are responsible for most cases of JORRP. Limited long-term, multi-institutional U.S. data exist on the association of vaccine uptake and JORRP incidence. Objective: To examine longitudinal changes over 19 years in JORRP incidence and management in the setting of rising HPV vaccination rates. Design: Retrospective cohort study. Methods: The authors queried the TriNetX U.S. Collaborative Network, an electronic health record database of approximately 118.9 million patients from 68 health care organizations, for children aged ≤18 years diagnosed with JORRP between January 2006 and December 2024. Annual encounter-based incidence of vaccination and JORRP was calculated. Use of adjuvant therapies such as bevaciz more...