CHR Designation Predicts Later Psychotic Disorders in Younger Samples

Background: The state of clinical high risk (CHR) describes individuals who have some psychotic features but who do not meet full criteria for a psychotic disorder. This phenomenon has been studied most extensively in adults, and less is known about the adolescent presentation and the rate of conversion to full psychotic disorders. Objective: To summarize the evidence on CHR in younger populations. Design: Systematic view and meta-analysis. Methods: The authors reviewed studies that examined the conversion of CHR to psychotic disorders with samples that had an average age of Results: 32 studies met the inclusion criteria, comprising a total of 2951 CHR patients, with an average age of 16.5 years. For most studies, the follow-up period was 12 to 24 months. One of the main findings was that the conversion rate to psychosis (overall, around 18%) was somewhat lower among studies that restricted the sample to those aged One factor that predicted a higher conversion rate was exposure to an more...