BAOS Improves Outcomes After Failed Thrombectomy in ICAD-Related Stroke

Background: Mechanical thrombectomy is the standard treatment for acute ischemic stroke (AIS) caused by large vessel occlusion (LVO). However, thrombectomy may fail or leave severe residual narrowing of the artery, particularly in strokes caused by intracranial atherosclerotic disease (ICAD). Persistent stenosis increases the risk of reocclusion and recurrent stroke. Bailout intracranial angioplasty or stenting (BAOS) is sometimes used to restore vessel patency, but prior results from the ANGEL-REBOOT (Randomized Study of Bailout Intracranial Angioplasty Following Thrombectomy for Acute Large Vessel Occlusion) trial did not show improved outcomes at 90 days. Objective: To determine whether BAOS improves 1-year functional outcomes in patients with LVO who have unsuccessful thrombectomy or severe residual stenosis. Design: Multicenter, prospective, open-label, randomized clinical trial with blinded outcome assessment conducted at 36 tertiary hospitals in China. Participants: Adults age more...