Single-Day Accelerated TMS Shows High Response, Sustained Remission in Depression

Background: Conventional transcranial magnetic stimulation (TMS) protocols for depression require daily treatments over several weeks, creating logistical barriers and limiting accessibility. Accelerated paradigms aim to condense treatment delivery while maintaining efficacy, although concerns remain regarding tolerability, durability, and real-world feasibility. Neuroplasticity-enhancing strategies, including pharmacologic augmentation and high-frequency session delivery, may further optimize outcomes, but clinical data outside controlled trials are limited. Objective: To evaluate the feasibility, safety, and real-world effectiveness of a single-day accelerated TMS protocol (ONE-D) augmented with neuroplasticity-enhancing medications in patients with depression. Design: Retrospective, open-label case series. Methods: Clinical data from 32 adults with unipolar depression (including prior TMS responders) were analyzed following a single-day accelerated TMS protocol. The intervention d more...