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Skin Synuclein Deposition Is Sensitive Biomarker for DLB

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Background: Dementia with Lewy bodies (DLB), one of the synucleinopathies, is the second most common neurodegenerative dementia, with some unique clinical and treatment features. The diagnosis can be difficult at times. A specific and sensitive biomarker would be very useful, especially in the development of early disease-modifying therapy. Objective: To investigate whether phosphorylated α-synuclein (p-syn) skin-nerve deposition could be useful in differentiating DLB from ot more...
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