Practical Reviews

Can the Periodontal Microflora Initiate MRONJ?


Background: Medication-related osteonecrosis of the jaw (MRONJ) is a serious side effect associated with bisphosphonate treatment. It is defined as exposed necrotic bone or bone that can be probed through an intraoral or extraoral fistula in the maxillofacial region after current or previous treatment with antiresorptive or antiangiogenic agents. It must have persisted for >8 weeks, with no history of radiation therapy or obvious metastatic disease of the jaw. Objective: To study t more...
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