Practical Reviews

p16 IHC Is Positive in More Than Just SCC in Oropharynx


Background: Clear cell carcinoma (CCC) of the salivary gland is a low-grade malignancy that can involve minor salivary glands of the oropharynx and oral cavity. CCC has a conserved cytogenetic abnormality, EWSR1-ATF1 gene fusion, and most CCC have areas of clear cell morphology. In some cases of CCC, there are few clear cells and instead a predominance of tumor cells with squamoid morphology that may connect to the surface epithelium. This raises the question of whether a CCC of th more...
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