Practical Reviews

Mesothelium as Possible Source of PEL


Background: Primary effusion lymphoma (PEL) is rare and most often seen in HIV+ patients as a body cavity lymphoma positive for both Kaposi sarcoma herpes virus (KSHV) and Epstein–Barr virus (EBV). Although PEL has some B-cell lymphocyte features, the origin of these cells remains unclear. Objective: To investigate the possibility of mesothelial-to-lymphoid transformation as a step in the development of PEL. Design/Methods: Mesothelial cells derived from patients with PEL and other more...
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