Practical Reviews

Large Variability of False-Positive Rate in National Lung Screening Trial


Background: The authors note that the National Lung Screening Trial (NLST) reported a 20% mortality benefit to 3 annual low-dose chest CT screenings compared with chest radiography. There were high rates (27%), however, of positive screenings; the majority (>90%) were false-positive nodules, which were found to be benign on repeated follow-up CT. Objective: To evaluate variability in radiologists' nodule detection rate, including evaluation of false-positive rates (FPRs) and sensit more...
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