Practical Reviews

Drug Available for Reversing Benzodiazepine Overdose

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Flumazenil (Romazicon ® ) is a drug indicated for benzodiazepine (BZO) overdose and reversal. Metabolism: Flumazenil is metabolized in the liver, and it has no active metabolites. The elimination half-life is relatively short (40 to 80 minutes), meaning that patients must be monitored for re-sedation for 2 or 3 hours after administration. Mechanism of Action: Flumazenil is a negative allosteric modulator. It works by displacing the BZO molecule from that BZO receptor binding site, more...
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