Practical Reviews

177Lu-DOTATATE May Be Effective for Advanced Neuroendocrine Malignancies


Background: High concentration of tumor cell surface somatostatin receptors is one of the many fascinating features of neuroendocrine tumors. Small peptide analogs of somatostatin which target these receptors have been labeled with both diagnostic and therapeutic radioisotopes. In the past 15 years a great deal of experience has been generated worldwide demonstrating the value of targeting these receptors with internally administered radiolabeled somatostatin analogues which emit b more...
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