Practical Reviews

Bupropion Helps With Smoking Cessation, Slows Weight Gain


For smoking cessation, 2 non-nicotine–based medications are available: bupropion and varenicline. Bupropion (Zyban ® ) was developed as an antidepressant and was found to also diminish the user’s desire to smoke. Bupropion is a relatively weak inhibitor of the neuronal uptake of norepinephrine, serotonin, and dopamine, and does not inhibit monoamine oxidase. The mechanism by which Zyban enhances the ability of patients to abstain from smoking is unknown, but this action is presumab more...
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