Practical Reviews

Oral Drugs Altered by Liver in First-Pass Hepatic Metabolism


Drug absorption describes the movement of the drug into the systemic bloodstream after the drug's administration. Oral drugs must move from the oral cavity into the esophagus, stomach, and the small intestine, which is where it is absorbed and moves into the bloodstream that drains directly to the liver. Therefore, the liver has the ability to metabolize oral drugs before they are able to move past the liver into the systemic circulation and have its clinical effect. Many parentera more...
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