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TDP-43 Aggregation Is Another Cause of Memory Impairment in the Elderly


Background: TAR DNA-binding protein 43 (TDP-43) aggregation in neurons causes most cases of frontal temporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Neuronal aggregation of several proteins (amyloid, tau, -synuclein) is associated with various "degenerative" neurological disorders, and increases with aging. Objective: To study the association of TDP-43 pathology with memory, other cognitive domains, and dementia in community-dwelling elders without pathol more...
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