Practical Reviews

An Important Variant of Early Onset Alzheimer Disease

Background: Posterior cortical atrophy (PCA) is a dementing disorder that begins with visuospatial symptoms followed later by cognitive deficits. This syndrome has a disputed history, but it is now considered a variant of Alzheimer disease (AD). Objective: To determine the nature of this syndrome (looking for evidence that it is a variant of AD), to define its natural history, and to show how it differs from other variants of early onset AD. Participants/Methods: Patients were enro more...
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