Practical Reviews

No Benefit for Levothyroxine in Geriatric Subclinical Hypothyroidism

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Background: Subclinical hypothyroidism, defined as a normal free thyroxine (fT4) level in the setting of an elevated thyrotropin/thyroid-stimulating hormone (TSH) level, is often asymptomatic. Epidemiologic studies, however, suggest associations between subclinical hypothyroidism and conditions such as coronary artery disease. Objective: To determine if levothyroxine treatment provides clinical benefit to older persons with subclinical hypothyroidism. Design: Multicenter, double-bl more...
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